Peer-reviewed research and clinical evidence supporting the technology inside every Exyross device.
The Bioscan
"Systematic review evaluating PBM as adjunct to gingival grafting. Found PBM improved wound healing and patient comfort in the post-operative period."
Read studyClinical Oral Investigations
"Split-mouth RCT evaluating a 980 nm diode laser as adjunct to SRP. Assessed clinical periodontal indices including probing depth and bleeding."
Read studyLasers in Medical Science
"Three-arm RCT comparing gingival grafts alone and grafts + photobiostimulation for root coverage in gingival recession."
Read studyBMC Oral Health
"PBMT preconditioning enhanced DFSC viability, migration, and osteogenic differentiation. Showed significantly greater bone regeneration."
Read studyPMC
"RCT using LED PBM (625nm, 660nm, 850nm). PBM significantly reduced gingival hypertrophy and inflammation compared to placebo."
Read studyDentistry Journal
"Integrative review of 23 RCTs. Found a general trend toward improvement in probing depth, bleeding on probing, and clinical attachment level."
Read studyLasers in Medical Science
"Systematic review finding that PBM appeared to enhance alveolar bone healing post-extraction and significantly improve implant stability."
Read studyInt. Journal of Clinical Medical Research
"PBM showed significantly higher Landry wound healing index and complete wound epithelialization compared to control groups."
Read studyPubMed
"Meta-analysis of 14 RCTs. PBMT group had significantly lower incidence of oral mucositis. Demonstrates PBM's efficacy for mucosal healing."
Read studyScientific Reports
"Found irradiation promoted cell proliferation, migration, and wound healing factor production by ROS induction."
Read studyPhotonics
"Concluded that photobiomodulation triggers photochemical mechanisms in cells that promote homeostasis and bone healing."
Read studyPMC
"Periodontal pocket depths were significantly reduced — 8 teeth with ≥4mm pockets showed no pockets after 5 months of treatment."
Read studyPhotomedicine and Laser Surgery
"Achieved new bone formation and wound healing sufficient to place implants without additional bone augmentation."
Read studyInt. Journal of Molecular Sciences
"Both wavelengths increased cell proliferation, modulated oxidative stress and inflammation markers, and decreased apoptosis susceptibility."
Read studyBMC Oral Health
"Complete wound epithelialization was 3.23× more likely at day 14 with PBM. Concluded PBM effectively improves gingival wound healing."
Read studyJournal of Endodontics
"LLLT promoted SCAPs proliferation, osteogenic differentiation, and expression of VEGF and TGFβ2 for revascularization."
Read studyDentistry Journal
"Systematic review of 29 studies on PBM for radiotherapy-induced oral mucositis. Made recommendations on intervention timing for pain relief."
Read studyLasers in Medical Science
"PBM group showed significantly higher bone surface and connectivity density at 45 days vs. control. Enhances early alveolar bone repair."
Read studyInt. Journal of Periodontics
"Test groups showed significantly greater reductions in Gingival Index, probing depth, and clinical attachment level at 9-month follow-ups."
Read studyLasers in Medical Science
"Consistently reported higher osteogenesis markers and greater bone density/trabeculae percentage with PBM. No side effects reported."
Read studyJournal of Clinical Periodontology
"Meta-analysis of 7 RCTs. LLLT showed significant short-term benefits over SRP alone for probing pocket depth and IL-1β levels."
Read studyScience Translational Medicine
"Landmark Harvard study demonstrating that low-power laser activates latent TGF-β1 via ROS generation, differentiating stem cells."
Read studyWorld Academy of Sciences Journal
"States PBM has demonstrated beneficial effects in post-surgical healing following gingivectomy, flap surgery, and grafting procedures."
Read articleCochrane Database
"Notes that proposed PBM mechanism involves photon-mediated dissociation of inhibitory nitric oxide, restoring ATP and reducing oxidative stress."
Read articleInt. Society for Oral Oncology
"Formally recommended PBM for the prevention of oral mucositis and associated pain. Represents the highest level of institutional expert endorsement."
Read articleWyss Institute at Harvard
"Our treatment modality does not introduce anything new to the body... Called the work a potential paradigm shift from replacing teeth to regenerating them."
Read articleScientific Reports
"Demonstrates LLLT upregulates key osteogenic markers in gingiva-derived mesenchymal stem cells — relevant to periodontal bone regeneration."
Read reviewJournal of Pharmacy and Bioallied Sciences
"Details how LLLT at 630–980nm promotes tissue healing, reduces inflammation, and stimulates osteoblasts for bone remodeling."
Read reviewPMC
"Explains how laser treatment enhances fibroblast attachment on periodontal disease root surfaces and promotes biocompatibility for PDL cell attachment."
Read reviewAntibiotics
"Details how irradiated light reduces inflammation by regulating immunocompetent cells and supports periodontal tissue healing."
Read reviewCureus
"Photobiomodulation promotes additional benefits in healing of bone and gingival tissue, and lessens side effects of periodontal surgery."
Read reviewJournal of Clinical Medicine
"PBM at 600–700nm improves proliferation of gingival fibroblasts. Key mechanism: cytochrome c oxidase absorbs photons → increases ATP."
Read reviewFrontiers in Physiology
"Demonstrated increased TGF-β1 synthesis (strong collagen stimulator), downregulation of pro-inflammatory cytokines, and increase in anti-inflammatory markers."
Read reviewAnnals of Biomedical Engineering
"Details how PBM activates transcription factors leading to increased expression of genes for cell migration, anti-inflammatory signaling, and antioxidant enzymes."
Read reviewDental Materials
"Of 153 studies, 130 reported positive effects. Concludes LLLT is a reliable, safe, and novel approach to treating oral/dental disorders."
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